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Similarly, dissolving microneedles (DMNs) for allopurinol delivery demonstrate sustained SU reduction in animal models, avoiding gastrointestinal toxicity (Singh et al., 2017)

Legaria, J., Rajsbaum, R., Muoz-Clares, R.A., Villegas-Seplveda, N., Simpson, J., Iturriaga, G.: Molecular characterization of two genes encoding betaine aldehyde dehydrogenase from amaranth

Conversely, MXRA8 protects gliomas from ferritin degradation-dependent ferroptosis through negatively regulating NCOA4 and upregulating FTH1, although the explicit mechanism remains uncertain[110]

First-line systemic therapies like methotrexate (MTX), cyclosporine A (CyA), and retinoic acid are effective but can induce adverse effects such as hypertension, hepatotoxicity, and renal impairment

This metabolized marker AITC-NAC suggested low exposure in T2D compared to healthy mice

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